What is Gynandroblastoma of the Ovary?
Gynandroblastoma of the Ovary is a rare ovarian tumor composed of granulosa cells and Sertoli-Leydig cells. It typically occurs in younger females but can develop at any age.
Disease Causes
Gynandroblastoma of the ovary is a rare type of ovarian tumour that contains both male and female cells. Mutations in the AKT1, FOXL2, and DICER1 genes are considered responsible for its development.
Signs and Symptoms
The patient may suffer from the following signs and symptoms:
- Excessive hair growth (Hirsutism)
- Abnormal bleeding from the vagina
- Infertility
- Acne
- Hair loss or baldness
- Hoarse voice
Diagnosis
Following diagnostic tests and procedures can be used to make the diagnosis:
- Complete blood count ( CBC)
- Serum tumour markers
- Imaging techniques like ultrasonography (USG), CT-scan, MRI, and X-Ray to detect the site, size, and extent of the tumour.
- Pelvic examination through per-speculum examination of the vagina, cervix, and ovaries. A speculum is a gynecological instrument used to visualise the vaginal wall, cervix, uterus, and ovaries to detect any abnormality.
Treatment
Surgery is the most common and effective treatment for gynandroblastoma of the ovary. In advanced, metastatic, or recurrent cases, chemotherapy and radiation therapy are the primary treatment options.
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