What is Transitional Cell Carcinoma of the Renal Pelvis with Squamous Cell Differentiation?Transitional cell cancer of the renal pelvis with squamous differentiation is cancer that arises from the transitional epithelial cells of the renal pelvis of the kidney and along with the presence of squamous cell squamous cells in the form of intracellular bridges or keratinization. In 20% of cases of transitional cell carcinoma of the renal pelvis squamous cell differentiation is found.
Disease CausesThere is no well-known cause, however, certain hereditary or genetic mutations are considered responsible for the development of renal transitional cell carcinoma with squamous cell differentiation. Cigarette smoking, kidney stones, Urinary bladder stones, chronic bacterial infection, and unnecessary use of pain relievers are risk factors for developing transitional cell carcinoma with squamous cell differentiation of the renal pelvis. The risk of developing squamous cell differentiation in transitional cell carcinoma of the renal pelvis is increases with advanced stage and grade of the tumor.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- Pain in the back
- Mass on side of the back
- Blood in the urine
- Frequent desire to pass urine
- Pain while passing urine
- Unintentional weight loss
- Constant Fever
- Constant Fatigue
- Loss of appetite
DiagnosisThe following diagnostic techniques and procedures can be used to make a diagnosis. These are
- Blood tests such as Complete blood count (CBC)
- Urine complete examination (Urine test)
- Diagnostic imaging techniques such as USG, CT-scan, MRI, and PET scan can be used to detect the site, size, and extent of the tumor.
- Tumor biopsy