What is Spindle Cell Carcinoma of the Lung?Spindle cell carcinoma of lung is a rare type of lung that arises from the spindle cells found in the peripheral area of lungs. It account for 0.2-0.3% of all lung cancers. It is a high grade tumor. High grade tumors are those that grow and spread to the other parts of the body. It is more common in males as compared to females. The mean age at the diagnosis of disease is 62 years.
Disease CausesThere is no well-known cause, but several hereditary and genetic mutations are thought to be responsible for the development of spindle cell carcinoma of lung. An association has also been observed between cigarette smoking and the development of spindle cell carcinoma of lung.
Signs and SymptomsSigns and symptoms depend on the extent and spread of the disease to other organs or parts of the body. If the cancer is limited to the lungs, the patient will only experience signs and symptoms of the respiratory system. At the same time, in cases where this cancer spreads to other parts of the body, the patient also experiences B symptoms of cancer.
General Respiratory Symptoms of Spindle Cell Carcinoma of the Lung
- Persistent cough
- Dyspnea (shortness of breath or difficulty in breathing)
- Chest pain that worsens with coughing, laughing and breathing deeply
- Coughing up blood
- Wheezing without having asthma history
- Clubbing of the fingers and nails (A physical sign characterized by a bulging extension at the ends of one or more fingers or toes).
The following are the general B symptoms (systemic symptoms) of spindle cell carcinoma of lungs when it spreads to other organs of the body. These are
- Night sweats
- Weight loss
- Bone pains
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are;
- Imaging techniques like Chest X-ray, CT-scan, MRI, and PET scan to see the site, size, and extent of the tumor.
- Tumor biopsy ( lung tumor biopsy to remove a small sample of lung tissue for histopathological examination)
- Sputum cytology
- USG guided fine needle aspiration cytology