What is Signet Ring Cell Adenocarcinoma?
Signet ring cell adenocarcinoma is a rare type of tumour characterised by the presence of at least 50% signet ring cells. Ninety percent of the cases start with the stomach’s glandular cells, but it can also start in other tissues such the testis, colon, rectum, gallbladder, breast, and stromal section of the ovaries.
Males are slightly more likely than females to get this carcinoma, which typically manifests before the age of 40. Signet ring cell adenocarcinoma is more common in those with ulcerative colitis and other inflammatory bowel disorders (IBD).
Disease Causes
A few cases of signet ring cell adenocarcinoma are hereditary which is caused by mutations in the CDH1 gene.
Signs and symptoms
Signs and symptoms depend upon the type of body organ from which the tumour arose. Here are the symptoms of signet ring adenocarcinoma of the colon:
- Pain in the abdomen
- Irregularities in bowel movement patterns
- Constipation
- Bleeding from the rectum
- Unintentional weight loss
Signs and symptoms of signet cell adenocarcinoma of the appendix, are
- Pain in the abdomen
- Inflammation of the appendix
- Ascites (The buildup of fluid in the abdomen, leading to abdominal distention)
- Mass or tumour in the abdomen
- Bowel obstruction (Inability to pass feces or gas)
Diagnosis
The following diagnostic tests and procedures can be used to make a diagnosis:
- Ultrasound (USG) of the abdomen
- Gastro-endoscopic examination of the stomach, anus, rectum, small intestine, and large intestine. Endoscopy is a procedure that allows the doctor to visualise the internal organs of the body directly through the endoscope.
- Computed Tomography (CT-pelvis) helps to differentiate the types of cancer cells
- Biopsy of the lesion/tumour and histopathological examination
- Barium Meal (Upper Gastrointestinal (GI) Series)
Treatment
Surgical removal of the tumour (cancerous part of the small intestine) is the main treatment option. Other treatment options are chemotherapy, radiation therapy, and targeted immunotherapy.
What support can we give for the Signet Ring cell Adenocarcinoma?
Signet ring cell adenocarcinoma of the lung is a rare cancer, meaning it is not as well-known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Signet ring cell adenocarcinoma, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
Donations — Without a Ribbon are grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.