What is Primary Peritoneal Serous Carcinoma?
Primary peritoneal serous carcinoma is a rare type of cancer that arises from peritoneal epithelial cells and is similar to serous ovarian cancer. This is a high-grade tumor that grows rapidly and spreads to other distant parts of the body. It shows a poor prognosis (chances of recovery) with a total life expectancy of 11-17 months after diagnosis.Disease Causes
Primary peritoneal serous carcinoma does not have a clear cause; however certain hereditary and genetic alterations, old age, female gender, and possession of the BRCA1 and BRCA2 cancer genes are significant risk factors.Signs and Symptoms
The patient may suffer from the following signs and symptoms. These are- Pain in the abdomen
- Distension of the abdomen
- Constipation
- Loss of appetite (hunger)
- Nausea
- Feeling of fullness even after taking a few bites of food
- Abnormal vaginal bleeding (bleeding other than menstruation)
- Frequent need to go to the toilet to pass urine
- Unexplained weight loss
- Fever
- Excessive sweating
- Weakness
Diagnosis
- Physical examination of the abdomen and pelvis ( doctor examines the body to find out any mass or tumor in the abdomen and hip region)
- Per-speculum vaginal examination
- USG-guided fine needle aspiration cytology
- Computerized tomography (CT-scan) of the abdomen and pelvis
- Magnetic resonance imaging (MRI ) of the ovaries along with the whole abdomen and pelvis
- Immunohistochemistry for CK7, ER, and CA-125