What is Nodular Sclerosis Hodgkin’s Lymphoma?Nodular sclerosis Hodgkin’s lymphoma is a subtype of leukocyte cancer (white blood cells cancer) that is characterized by the presence of collagen fibers surrounding Hodgkin-Reed-Sternberg cells in the lymph nodes on histological examination of tissue biopsy (observation under a microscope). The most common sites for the development of nodular sclerosis classical Hodgkin’s lymphoma are cervical lymph nodes (lymph nodes of the neck), lymph nodes of the mediastinum ( chest cavity lymph nodes), liver, spleen, lungs, bones, and bone marrow.
Disease Etiology (Causes)There is no well-known cause, but there has been an association between the development of classic Hodgkin’s lymphoma of nodular sclerosis and previous or ongoing Epstein-bar virus (EBV) infection.
Disease EpidemiologyIt accounts for approximately 70% of all classic Hodgkin’s lymphomas. This is more common in the upper socio-economic class group. It is equally common in both men and women. The average age at onset of the disease ranges from 15 to 34 years.
Signs and SymptomsThe Nodular sclerosis classical Hodgkin’s lymphoma presents with the general symptoms of cancer. These are
- Night sweats
- Weight loss
- Constant Tiredness
DiagnosisThe following are the diagnostic tests that help diagnose the lymphocyte depleted classical Hodgkin’s lymphoma.
- Complete blood count (CBC) with peripheral smear
- Blood coagulation profile
- Bone marrow aspiration and cytology
- EBV antibodies test
- CT- scan, MRI, PET scan, Ultrasonography (USG), and X-Ray to detect the site and extent of cancer.