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Melanoma of the Urethra – Symptoms, Treatment & Support

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Posted by Matthew O’Connor | May 30, 2023

What is Melanoma of the Urethra or Urethral Melanoma?

Melanoma of the urethra is an extremely rare and aggressive form of cancer that arises from melanocytes, the cells that produce the pigment melanin, found in the skin and mucous membranes, including the urethra. This type of cancer is very rare, accounting for less than 1% of all urethral malignancies.

Symptoms

Symptoms of urethral melanoma may include:
  • Blood in the urine (hematuria)
  • Frequent urination or a persistent urge to urinate
  • Pain during urination (dysuria)
  • A lump, mass, or pigmented lesion in the area of the urethra
  • Weak or interrupted urine flow

Disease Aetiology (Causes)

The exact cause of urethral melanoma is unknown. However, like other melanomas, it likely involves genetic mutations in melanocytes that lead to uncontrolled cell growth.

Diagnosis

The diagnosis of urethral melanoma often involves:
  • Detailed medical history and physical examination
  • Biopsy of the suspicious lesion for microscopic examination and immunohistochemical staining to confirm the presence of melanocytes
  • Imaging tests such as ultrasound, CT scan, or MRI to determine the extent of the cancer

Treatment

The treatment for melanoma of the urethra typically involves:
  • Surgery: The primary treatment, often involving wide local excision of the tumour. In some cases, more extensive surgery may be needed, such as partial or total urethrectomy.
  • Immunotherapy: Drugs that stimulate the immune system to attack cancer cells may be used, especially for more advanced cases.
  • Targeted therapy: Drugs that specifically target mutations found in melanoma cells may be used.

What Support can we Give for Melanoma of the Urethra?

Melanoma of the Urethra is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Melanoma of the Urethra, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!

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You can help us with your donation:

Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
Donations — Without a Ribbon are grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.

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PreviousSquamous Cell Carcinoma of the Urethra – Symptoms, Treatment & Support
NextUrachal Adenocarcinoma of the Ureter

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