What is Histiocytosis?
Histiocytosis is the uncontrolled and excessive production of histiocytes. Histiocytes are white blood cells, also called macrophages. Bone marrow-derived histiocytes fight bacteria, viruses, and other pathogens of foreign diseases that enter the body. The spleen, liver, bone marrow, lymph nodes, brain, and spinal cord are the most commonly affected sites.Disease Epidemiology
It is a very rare cancer, with an annual incidence of 1 in 200,000 children in the United States. Histiocytosis most often affects children under 10 years of age, but it can also develop in adults.Disease Etiology (Causes)
There is no well-known cause; however certain genetic mutations (alteration in genes), autoimmune diseases, and viral infections are responsible for the development of histiocytosis.Signs and Symptoms
Signs and symptoms depend upon the involvement of the organ system and their degree of involvement. The most common symptom is a pain in the affected area or part of the body.Diagnosis
Serological, radiological, and biopsy investigations are useful to diagnose. These are:- Complete blood count (CBC) with peripheral smear and blood culture
- Blood coagulation profile
- LFT’s(Liver function tests) and RFT’s( Renal function tests)
- Bone marrow aspiration and biopsy
- Chest X-ray, CT chest
Treatment
Treatment options include chemotherapy, stem cell transplantation, supportive care, and treatment for relapse.What Support can we Give for Histiocytosis?
Histiocytosis is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Histiocytosis we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
