What is a High-grade Serous Carcinoma?
High-grade serous carcinoma (HGSC) originates from the uncontrolled division of the serous epithelial layer in the abdomen or pelvic cavity, but it usually develops within the serous epithelial layer of the ovary. The prognosis for patients with high-grade serous carcinoma of the ovaries is poor.
This differs from low-grade serous carcinoma of the ovary, which originates from the serous epithelial layer of the ovary and remains localized, not spreading to other parts of the body. Low-grade serous carcinoma is less aggressive and responds well to platinum-based chemotherapy.
Disease causes
The exact cause of high-grade serous carcinoma of the ovary, fallopian tube, and other abdominal and pelvic organs remains unknown. Nonetheless, it is recognised that a number of inherited genetic, environmental, gender, and age-related factors influence its development.
Studies show that more than 20% of ovarian high-grade serous carcinoma patients have a genetic basis. Menopausal hormone therapy, endometriosis, polycystic ovarian syndrome, and delayed first pregnancy are additional significant factors.
Signs and symptoms
The patient may suffer from the following signs and symptoms. These are
- Rapid weight loss
- Bloating of the abdomen
- Loss of appetite
- Abnormal bleeding from the vagina
- Abnormal bleeding between the menstrual cycle
- Abnormal discharge from the vagina
- Pain in the abdomen or hip region
Diagnosis
Following diagnostic tests and procedures can be used to make the diagnosis:
- Complete blood count ( CBC)
- Serum tumour markers
- Imaging techniques like ultrasonography (USG), CT scan, MRI, and X-Ray are utilsed to detect the location, size, and extent of the tumour.
- A pelvic examination involves a per-speculum inspection of the vagina, cervix, and ovaries. A speculum is a gynecological instrument used to visualise the vaginal walls, cervix, uterus, and ovaries to detect any abnormality.
- CA-125
Treatment
Laparoscopic surgical removal of the tumour is the first-line treatment for localised ovarian tumours. .In advanced cases of high-grade serous carcinoma of the ovary, a total abdominal hysterectomy is a treatment option. Other options are chemotherapy and radiation therapy, with the cancer responding well to platinum-based chemotherapy.
What support can we give for the Sarcomatoid cancer of the lung?
High-grade serous carcinoma is a rare cancer, meaning it is not as well-known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as High-grade serous carcinoma, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
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