What is the Goblet Cell Carcinoid of the Rectum?Goblet cell carcinoid is cancer that originates from neuroendocrine that is found in the appendix of human beings. Neuroendocrine cells are the cells that have characteristics of the nerve and hormone-producing cells. Goblet carcinoid of the rectum involves two types of cells which are neuroendocrine cells and epithelial cells. This is a very rare type of cancer that occurs in one person in every two million people. These cancer cells produce an excessive amount of mucin which with the help of water converts into mucus. The mean age for the development of goblet cell carcinoid of the rectum is the 5th and 6th decade of life. The overall 5-year survival rate is 76%. It is more common in females than males. It is more common in people of white ethnicity.
Disease CausesThere is no well-known cause, but several hereditary and genetic mutations, along with a parasitic infection known as schistosomiasis, are thought to be responsible for the development of goblet cell carcinoids in the rectum.
Sign and Symptoms
- Pain in the lower part of the abdomen
- Unintentional weight loss
- Felt able mass or tumor in the abdomen
- Bleeding from the rectum
- Bleeding with stool
- Difficulty in the passing stool due to the blockage of intestines by cancer cell
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are
- Ultrasound (USG) of the abdomen
- Endoscopic examination of the anus, rectum, and large intestine. Endoscopy is a procedure that allows the doctor to visualize the internal organs of the body directly through the endoscope.
- Computed tomography (CT-pelvis) helps to differentiate squamous cell cancer of the rectum from anal cancer.
- Biopsy of the lesion/tumor and histopathological examination
- Barium Meal