What is Glioblastoma?Glioblastoma is a type of brain cancer that develops from glial cells in the brain. Glial cells are cells that support the internal environment of the brain and spinal cord, provide nutrition and protection. It is aggressive cancer with a 5-year survival rate of 5-7%. It also tends to relapse.
Disease Etiology (Causes)There is no well-known cause; however previous exposure to radiation or radiation therapy and certain genetic disorders (diseases) such as neurofibromatosis and Li-Fraumeni syndrome are the risk factors that can cause glioblastoma.
Disease EpidemiologyThese are rare cancers, accounting for approximately 15% of all brain cancers. The annual frequency of the occurrence of glioblastoma is 3 in 100,000 people. It is more common in males than in females. The mean age for the development of the disease is 64 years.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- Constant headache
- Changes in mood and behavior
- Blurred vision
- Difficulty in speaking
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are
- Imaging tests such as X-Ray, CT-scan (computerized tomography), PET-scan (Positron emission tomography) help detect the site, size, and location of the tumor.
- Tumor biopsy and histopathological examination