What is Giant Cell Fibroblastoma?It is a rare, childhood, soft-tissue tumor of intermediate malignancy characterized by the presence of painless nodules in the dermis and subcutaneous layer of the skin. An intermediate tumor is a tumor that is in between the benign (slowly growing and unlikely to spread) and malignant (rapidly growing and have a tendency to spread) tumor.
Disease Etiology (Cause)A mutation in a certain gene is the cause behind the development of giant cell fibroblastoma.
Disease EpidemiologyIt is most prevalent in children under the age of 10 years. Painless subcutaneous nodules usually develop at the head, neck, chest, abdomen, and extremities. It is more common in males as compared to females. In 50% of the cases, there is a chance of reoccurrence but metastasis (spread to the other parts of the body) is not observed in patients with Giant cell Fibroblastoma.
Signs and symptoms
- Presence of painless hard nodules.
DiagnosisFollowing diagnostic tests and procedures can be used to make a diagnosis.
- Nodule biopsy
- Histoctytology of the nodule