What is Diffuse Large B cell Lymphoma?
It is a type of white blood cell cancer that originates from B –cells or B lymphocyte. B cells are responsible for producing antibodies. Antibodies are proteins that are produced by our immune system of the body and help the body to fight against infectious agents. The most common sites for diffuse large B-cell lymphoma are the groin, armpits, and neck; less commonly, DLBCL can develop in the stomach, ovaries, testes, uterus, adrenal glands, thyroid gland, and bones.
Disease Epidemiology
The frequency of the occurrence of the disease in the US and UK population is 7-8 cases per 100,000 people annually. It mostly affects the older population with a mean age at diagnosis is 70 years.
Disease Etiology (Causes)
There is no definite, well-defined cause, but certain mutations (changes) in growth-regulating genes that are responsible for normal B-lymphocyte growth and division, and risk factors such as immunodeficiency, previous history of Epstein-Barr virus (EBV) infection, Helicobacter pylori and exposure to HIV (Human Immunodeficiency Virus) are thought to be responsible for diffuse large B-cell lymphoma.
Signs and Symptoms
The patient may suffer from the following signs and symptoms. These are
- A rapidly growing mass or lump most commonly develops in groin and armpits or neck.
- Fever
- Night sweats
- Unexplained weight loss
Diagnosis
- Imaging techniques like X-ray, USG (ultrasonography), MRI, CT-Scan, and PET –scan to detect the size and extent of the tumor.
- Tumor biopsy and histopathological examination
- Serum Lactate dehydrogenase (LDH)
Treatment
Treatment options are radiation therapy and chemotherapy.
What Support can we Give for Diffuse Large B Cell Lymphoma?
Diffuse Large B Cell Lymphoma is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Diffuse Large B Cell Lymphoma, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
