What is Liposarcoma?
It is a rare type of cancer that originates from the fat cells or tissues of the body. The most common sites of its origination are the thighs and retroperitoneum (abdominal cavity/space behind the peritoneum) of the abdomen; however, it can develop in any part or site of the body.
What is Dedifferentiated Liposarcoma?
Dedifferentiated liposarcoma is a high-grade tumour that is the combination of well-differentiated and poorly differentiated liposarcoma and non-lipomatous sarcoma. In 10-15% of cases, it can spread to the other parts of the body from its site of origin.
It makes approximately 10% of differentiated liposarcoma. Most commonly it originates from the retroperitoneum (abdominal cavity/space behind the peritoneum) of the abdomen. However, other frequently involved sites are arms, legs, spermatic cord in male, head, and neck. It is common in adults as compared to children and slightly more prevalent in males as compared to females.
Disease Etiology (Causes)
There is no exact well-known cause is found. Certain genetic mutations are considered responsible for the development of the Tumor.
Signs and Symptoms
Most dedifferentiated liposarcoma patients have no symptoms until the tumour is large and puts pressure on adjacent structures, causing tenderness, pain, or functional disorders. The patient may have the following signs and symptoms. These are
General (Overall) Symptoms Associated with the Dedifferentiated Liposarcoma
- Ulceration of the tumour or injury of the adjacent regions.
- Painful swelling
- Weight loss
- Fatigue and lethargy
- Night sweats
Signs and Symptoms of Dedifferentiated Liposarcoma of the Lower Limb (leg)
- Numbness of the affected limb
- Enlargement and swelling of lower leg veins.
- Fatigue and Lethargy
Signs and Symptoms Associated with Dedifferentiated Liposarcoma of the Abdomen (Retroperitoneum)
- Palpable ( touchable) Abdominal mass/lump
- Abdominal Pain
- Nausea Vomiting
- Weight loss
Definite diagnostic tests to diagnose the liposarcoma tumours are tumour biopsy and histopathology, Fine needle aspiration cytology, and cytogenetic study of the specimen. Radiological techniques like CT scan, MRI, USG, and X-ray also recommended locating the size and site of the tumour.
For the tumour which is not widespread, wide local surgical excision of the tumour is the most effective treatment option. Chemotherapy and radiotherapy are the treatment options for tumours that spread to distant parts of the body and are not confined to their site of origin.
What Support can we Give for Dedifferentiated Liposarcoma?
Dedifferentiated Liposarcoma is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Dedifferentiated Liposarcoma we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways: