What is Liposarcoma?It is a rare type of cancer that originates from the fat cells or tissues of the body. The most common sites of its origination are the thighs and retroperitoneum (abdominal cavity/space behind the peritoneum) of the abdomen; however, it can develop in any part or site of the body.
What is Dedifferentiated Liposarcoma?Dedifferentiated liposarcoma is a high-grade tumour that is the combination of well-differentiated and poorly differentiated liposarcoma and non-lipomatous sarcoma. In 10-15% of cases, it can spread to the other parts of the body from its site of origin.
Disease EpidemiologyIt makes approximately 10% of differentiated liposarcoma. Most commonly it originates from the retroperitoneum (abdominal cavity/space behind the peritoneum) of the abdomen. However, other frequently involved sites are arms, legs, spermatic cord in male, head, and neck. It is common in adults as compared to children and slightly more prevalent in males as compared to females.
Disease Etiology (Causes)There is no exact well-known cause is found. Certain genetic mutations are considered responsible for the development of the Tumor.
Signs and SymptomsMost dedifferentiated liposarcoma patients have no symptoms until the tumour is large and puts pressure on adjacent structures, causing tenderness, pain, or functional disorders. The patient may have the following signs and symptoms. These are
General (Overall) Symptoms Associated with the Dedifferentiated Liposarcoma
- Ulceration of the tumour or injury of the adjacent regions.
- Painful swelling
- Weight loss
- Fatigue and lethargy
- Night sweats
Signs and Symptoms of Dedifferentiated Liposarcoma of the Lower Limb (leg)
- Numbness of the affected limb
- Enlargement and swelling of lower leg veins.
- Fatigue and Lethargy
Signs and Symptoms Associated with Dedifferentiated Liposarcoma of the Abdomen (Retroperitoneum)
- Palpable ( touchable) Abdominal mass/lump
- Abdominal Pain
- Nausea Vomiting
- Weight loss