What is a Cytokeratin-Positive Interstitial Reticulum Cell Tumor?
A cytokeratin-positive interstitial reticulum cell tumor is a rare tumor (abnormal cell growth) in the lymph nodes, spleen, and tonsils. The most common sites for this tumor are the lymph nodes in the neck, ear, collarbone, chest, and abdomen.Disease Etiology (Causes)
There is no well-known cause; however, certain genetic mutations are responsible for the development of Cytokeratin-positive interstitial reticulum cell tumor. Signs and symptoms The patient may suffer from the following signs and symptoms. These are- Fever
- Night sweats
- Weight loss
- Pain at the tumor site
- Abnormal enlargement of the spleen, lymph nodes, or tonsils
For example, a patient with mediastinal (thoracic) lymph nodes involvement has the following signs and symptoms. These are
- Cough
- Chest pain
- Bloody sputum
- Difficulty in breathing
A patient with retroperitoneal (abdomen) lymph nodes involvement has the following signs and symptoms. These are
- Pain in abdomen
- Discomfort in the abdomen
- Superficial skin lymph nodes are painless and swollen
Diagnosis
The following diagnostic techniques and procedures can be used to make a diagnosis these are- Complete blood count (CBC)
- Diagnostic imaging techniques such as USG, CT-scan, MRI, and PET scan can be used to detect the site, size, and extent of the tumor.
- Immunophenotyping
- Cytogenetics
- Bone marrow biopsy