What is Fibrous Dysplasia (FD) of The Bone?Fibrous dysplasia is a rare congenital bone disorder in which fibrous (scar-like) tissues develop in place of normal bone cells due to a defect in the differentiation and maturation of bone-forming cells. This defect can cause deformation and fracture of the affected bone. It usually affects one area of bone, but it can affect multiple areas of more than one bone. Individual bone lesions are commonly reported in adolescents and young adults. While cases of multiple bone lesions were usually observed in children under 10 years of age. Fibrous bone dysplasia can affect any bone in the body, but in most cases, it usually affects the femur (femur), tibia (lower leg), bones of the upper arm (humerus), skull bones, ribs, and pelvis.
Disease Etiology (Causes)The likely cause is the genetic mutation (defected alteration) in bone-forming cells of the body.
Disease EpidemiologyFibrous dysplasia is more common in children and young adults, as 75% of reported cases are in the age group under 30. This is equally common in both men and women. Signs and symptoms The patient may suffer from the following signs and symptoms. These are
- Pain in bones that lead toward sleeplessness
- Unexplained Swelling of the bones
- Bones deformities
- Fracture in the bones (particularly fractures in the arms and legs bones)
- Curved shape bone legs
DiagnosisThe following diagnostic techniques and procedures can be used to make a diagnosis these are
- Complete blood count (CBC)
- Diagnostic imaging techniques such as USG, CT-scan, MRI, and PET scan can be used to detect the site, size, and extent of the tumor.
- Bone marrow biopsy