What is Angioimmunoblastic T-cell Lymphoma?It is a type of white blood cell cancer that originates from the uncontrolled division or multiplication of the T-lymphocytes. T-cells, or T lymphocytes, are the main components of the body’s immune system that helps to fight infections.
Disease EpidemiologyIt accounts for one to two percent of all white blood cell cancers. It is more common in older people.
Disease CausesThere is no well-known cause, however, it is believed that overactive or malfunctioning of the immune system is the likely cause of the development of angioimmunoblastic T-cell lymphoma.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- High-grade fever
- Excessive sweating at the night
- Unexplained weight loss
- Rashes on the skin
- Enlargement of multiple lymph nodes of the body
- Constant fatigue
- The difficulty in breathing
- Enlargement of the liver
- Due to the frequent involvement of bone marrow patients may also present with the symptoms of anemia (decreased RBCs count or decreased oxygen-carrying capacity of the blood), lethargy, difficulty in breathing, and weakness.
- Thrombocytopenia: decreased platelet leading to a tendency to bleeding and bruising on the skin.
DiagnosisThe following diagnostic techniques and procedures can be used to make a diagnosis these are
- Complete blood count (CBC)
- LFT’s (Liver function test)
- Renal function tests
- Diagnostic imaging techniques such as USG, CT-scan, MRI, and PET scan can be used to detect the site, size, and extent of the tumour.
- Lumbar puncture Test
- Tumour biopsy and histopathology