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Aggressive Digital Papillary Adenocarcinoma

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Posted by fatima.shakeel@opmc.co | Aug 15, 2025

What is Aggressive Digital Papillary Adenocarcinoma?

Aggressive Digital Papillary Adenocarcinoma is a rare and serious form of cancer that starts in the sweat glands of the fingers or toes. The word “digital” refers to fingers or toes, and “adenocarcinoma” means a cancer that begins in glandular tissue.

This type of cancer is more commonly seen in adult men, but it can affect women as well. It usually appears as a small, painless lump on the tip or side of a finger or toe, which can be mistaken for a harmless cyst, wart, or boil.

Symptoms

The lump might stay the same for some time, but over weeks or months, it can begin to grow quickly. It may become painful, develop a sore, or even start to ooze fluid or bleed.

Because it starts out looking harmless, many people delay getting it checked, and the cancer may grow or spread before it is diagnosed. In some cases, this cancer can spread to the lungs or nearby lymph nodes, which makes early diagnosis very important.

Diagnosis

Diagnosis depends on how the lump looks and behaves. To confirm it, they perform a biopsy by removing a small sample of the lump and examining it under a microscope. If cancer cells are found, further tests like X-rays or CT scans may be done to check if the cancer has spread.

Treatment

Treatment mainly involves surgery. In many cases, the affected part of the finger or toe may need to be removed to ensure that all cancer cells are taken out. If the cancer has spread or comes back, additional treatments like chemotherapy may be considered. This cancer is called “aggressive” because it tends to return even after it has been removed, so patients need regular follow-up care after surgery.

Prognosis

The overall outcome depends on how early the cancer is diagnosed and treated. If found early and completely removed, people have a good chance of recovery. However, if treatment is delayed or if the cancer spreads, it can be more difficult to manage. Because this cancer can come back, doctors usually recommend follow-ups for several years after the initial treatment.


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