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What is Pancreatic Undifferentiated Carcinoma with Osteoclast-like Giant Cells?

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Posted by fatima.shakeel@opmc.co | Jul 13, 2025

Pancreatic Undifferentiated Carcinoma with Osteoclast-like Giant Cells is a very rare and aggressive cancer that starts in the pancreas. The pancreas is an organ located behind the stomach that helps with digestion and controls blood sugar.

In this type of cancer, the tumour contains special cells called “osteoclast-like giant cells,” which are large cells that look like bone cells under the microscope. These giant cells are not cancerous themselves, but their presence makes this cancer different from other forms of pancreatic cancer.

Symptoms

This disease is usually found in older adults, and it tends to grow quickly. People with this cancer often experience symptoms such as upper abdominal pain that may spread to the back, weight loss, loss of appetite, nausea, and sometimes jaundice, which is a yellowing of the skin and eyes. Because these symptoms can be caused by many other problems, the cancer is often diagnosed at a later stage when it has already grown or spread.

Diagnosis

To diagnose Pancreatic Undifferentiated Carcinoma with Osteoclast-like Giant Cells , doctors perform imaging tests like a CT scan or MRI to look at the pancreas. A biopsy is then done to remove a small piece of the tumour. When the sample is looked at under a microscope, the pathologist will see undifferentiated cancer cells mixed with the large osteoclast-like cells, which helps confirm the diagnosis.

Treatment 

Treatment usually includes surgery to remove the tumour, but this is only possible if the cancer has not spread too far. After surgery, chemotherapy is often given to kill any remaining cancer cells. In some cases, radiation therapy may also be used. If surgery is not an option, chemotherapy alone may be used to try to slow the cancer’s growth.

Prognosis

The outlook for this cancer is usually poor, as it grows quickly and often comes back after treatment. However, some studies suggest that people with this specific type, which includes the giant cells, may live slightly longer than people with other types of undifferentiated pancreatic cancer.

Still, it is a serious illness, and doctors are continuing to study it in hopes of finding better treatments. Regular medical care and support are very important for patients living with this condition.


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