What is Signet Ring Cell Carcinoma of the Colon?
Signet ring cell adenocarcinoma of the colon is a rare type of cancer of the large intestine and accounts for approximately 0.5 to 2.6% of adenocarcinoma colon. It is called signet ring cell adenocarcinoma due to the presence of signet ring cells as the dominant type of cancer cells and the formation of immature glands of the colon. It shows a poor prognosis (likely course of the disease). It usually affects adolescents and younger adults. Signet ring cell carcinoma of the colon has a higher tendency to involve the lymph nodes. The five-year survival rate of signet cell carcinoma of the colon ranges from 9-30%.Disease Causes
There is no well-known cause, however, certain hereditary and genetic mutations such as mutations in the CDH1 gene are considered responsible for the development of signet ring cell carcinoma of the colon.Signs and Symptoms
It is usually diagnosed in advanced stages, so the prognosis is poor (Likely course of the disease).- Vomiting
- Loose motion with blood in stool
- Pain in the abdomen
- Mass or tumour in the abdomen
- Change in bowel habits, constipation, diarrhea, or more frequent urge to pass stool.
- Dark colour stool due to the presence of blood in the stool
- Feeling as if the bowels are not empty after defecation
- Bleeding from the anus
- Unexplained weight loss
- Fatigue
- Constant Fever
Diagnosis
The following diagnostic tests and procedures can be used to make a diagnosis. These are- Endoscopic examination of the anus, rectum, and large intestine. Endoscopy is a procedure that allows the doctor to visualize the internal organs of the body directly through the endoscope.
- Computed tomography (CT-pelvis)
- Chest X-Ray or CT-Chest
- Biopsy of the lesion/tumour and histopathological examination
- Complete blood count
- LFTs (Liver Function test)
- Test for carcinoembryonic antigen (CEA)
- Colonoscopy
Treatment
Surgical removal of the tumour is the main treatment option. Other treatment options are chemotherapy and radiation therapy. Chemotherapy is very less effective in cases of signet ring cell carcinoma of the colon.What Support can we Give for Signet Ring Cell Carcinoma of the Colon?
Signet Ring Cell Carcinoma of the Colon is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Signet Ring Cell Carcinoma of the Colon, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
