What is Retroperitoneal Leiomyosarcoma?Retroperitoneal leiomyosarcoma is a type of cancer that arises from the large blood vessels lying behind the abdominal cavity called the peritoneum. It is usually developed in the 5th and 6th decade of life but may also affect children between the age of 5,6 years. It usually grows in size before diagnosis.
What is Retroperitoneum?The retroperitoneum is an anatomical space located behind the abdominal cavity. The organs of the abdominal cavity, such as the kidneys, adrenal glands, pancreas, nerve roots, large vessels of the abdominal cavity, and the inferior vena cava, are located in the retroperitoneal space.
Disease CausesIt is the second most common cancer of the abdomen or retroperitoneum. There is no well-known cause, however, some hereditary and genetic mutations (changes in the DNA sequence) are considered responsible for the development of retroperitoneal leiomyosarcoma. Some risk factors, such as previous radiation therapy, and exposure to certain chemicals such as pesticides, are powerful risk factors for developing retroperitoneal leiomyosarcoma.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- Pain in the abdomen
- Lump or mass in the abdomen
- Loss of appetite
- Bloating in abdomen
- Unintentional weight loss
- Constant Fatigue
- Constant fever
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are;
- Imaging techniques like ultrasound of the abdomen, CT-scan, MRI, and PET scan to see the site, size, and extent of the tumor.
- Tumor biopsy (tumor biopsy to remove a small sample of tissue for histopathological examination)
- USG guided fine needle aspiration cytology