What is Pleomorphic Carcinoma of Lung?
Pleomorphic carcinoma of the lung is a rare form of high-grade lung cancer. High-grade cancer is a cancer that grows rapidly and spreads to other parts of the body from where it originated. It account for approximately 0.1% to 0.4% of all lung cancers. The mean age for the diagnosis of disease in most cases was 60-65 years. It is more common in males as compared to females. It shows poor prognosis (likely course of the disease). The most common sites for the spread of the tumour from its site of origin are brain, adrenal glands, kidneys, small intestine, large intestine and rectum.
There is no well-known cause, but several hereditary and genetic mutations are thought to be responsible for the development of pleomorphic carcinoma of the lung. An association has also been observed between cigarette smoking and the development of pleomorphic carcinoma of lung. It
Signs and Symptoms
Signs and symptoms depend on the extent and spread of the disease to other organs or parts of the body. If the cancer is limited to the lungs, the patient will only experience signs and symptoms of the respiratory system. At the same time, in cases where this cancer spreads to other parts of the body, the patient also experiences B symptoms of cancer. General respiratory symptoms of pleomorphic carcinoma of the lung
- Persistent cough
- Dyspnea (shortness of breath or difficulty in breathing)
- Chest pain that worsens with coughing, laughing and breathing deeply
- Coughing up blood
- Wheezing without having an asthma history
- Clubbing of the fingers and nails (A physical sign characterized by a bulging extension at the ends of one or more fingers or toes).
The following are the general B symptoms (systemic symptoms) of the pleomorphic carcinoma of lung when it spreads to other organs of the body. These are
- Night sweats
- Weight loss
- Bone pains
The following diagnostic tests and procedures can be used to make a diagnosis. These are;
- Imaging techniques like Chest X-ray, CT-scan, MRI, and PET scan to see the site, size, and extent of the tumor.
- Tumour biopsy (lung tumour biopsy to remove a small sample of lung tissue for histopathological examination)
- Sputum cytology
- USG-guided fine needle aspiration cytology
Treatment Treatment options include surgical resection of the tumor, Chemotherapy, Radiotherapy, targeted therapy, and immunotherapy. Surgery is the main option, all patients with stages I carcinoma of the lung should undergo surgical resection of the tumor (complete removal of the tumor along with the removal of some surrounding healthy tissues). Chemotherapy and radiotherapy should be considered in advance cases of cancer.
What Support can we Give for Pleomorphic Carcinoma of Lung?
Pleomorphic Carcinoma of Lung is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Pleomorphic Carcinoma of Lung, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
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