What is a Placental Site Trophoblastic Tumour?
Placental site trophoblastic tumour is a rare form of early pregnancy tumours that arises from the trophoblastic cells. Trophoblastic cells are the cluster of cells that form the outer layer of fertilised egg, these cells provides nutrition to the developing embryo and makes the large part of the placenta.
The tumour is invasive in nature and has the tendency to spread to the muscles of the uterus and blood vessels. It can also spread into the distant parts of the body such as lymph nodes, lungs and pelvis.
Disease Causes
The unchecked division of trophoblastic cells, which proliferate to produce the placenta, results in placental site trophoblastic tumours. This typically appears during an abortion, miscarriage, molar pregnancy, or if there is any placental tissue remaining in the uterus following a typical pregnancy and delivery.
Signs and Symptoms
The patient may suffer from the following signs and symptoms:
- Bleeding from Vagina
- Absence of menstruation
Diagnosis
The following diagnostic techniques and procedures can be used to make a diagnosis:
- Dilatation and Curettage
- Hysterectomy
Treatment
The main treatment of placental site trophoblastic tumour is dilatation and curettage with adjuvant chemotherapy. Placental site trophoblastic tumour has a better disease outcome in cases where the tumour is restricted to uterus and the gap between the previous pregnancy and treatment is less than 2 years.
Platinum containing chemotherapy is the right treatment option for the high-risk placental site trophoblastic tumour.
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