What is nodular lymphocyte-predominant Hodgkin Lymphoma?Nodular Lymphocyte predominant Hodgkin lymphoma is a type of Hodgkin’s lymphoma (white blood cell cancer) but it grows more slowly than classical white blood cell cancer.
Disease EpidemiologyIt is approximately 5-10% of all Hodgkin’s lymphomas. It occurs in men 3 times more often than in women. The average age of onset of the disease is 30-40 years.
Disease causesRepetitive mutations (erroneous changes) in certain genes are thought to be responsible for the development of Hodgkin’s lymphoma with a predominance of nodular lymphocytes.
Signs and symptomsThe patient may suffer from the following signs and symptoms. These are
- Enlarged and swollen lymph nodes
- It can also occur in children
- Very few patients can suffer from B symptoms in earlier stages of the disease. B symptoms are
- Constant fever
- Night sweats
DiagnosisThe following are the diagnostic tests that help diagnose the nodular lymphocyte Predominant Hodgkin lymphoma.
- Complete blood count (CBC) with peripheral smear
- Blood coagulation profile
- Bone marrow aspiration and cytology
- EBV antibodies test
- CT- scan, MRI, PET scan, Ultrasonography (USG), and X-Ray to detect the site and extent of care.
- In cases where a person has had no signs or symptoms, only close surveillance of lymphoma is recommended.
- In early-stage (NLPHL) patients without B symptoms (persistent fever, night sweats, and weight loss), regional radiation therapy is the main treatment option.
- However, in cases where the tumor is large and causes B symptoms, chemotherapy followed by radiation therapy is the main treatment option. Other treatment options are targeted therapy and immunotherapy.