What is Malignant Fibrous Histiocytoma of the Bone?
Malignant Fibrous Histiocytoma of the bone, also known as undifferentiated high-grade pleomorphic sarcoma of the bone, is a rare and aggressive cancer that originates from the connective tissue cells in the bone. Although MFH is more commonly found in soft tissues, its occurrence in the bone represents a serious condition characterized by rapidly growing tumours that can metastasize to other parts of the body.
Symptoms of Malignant Fibrous Histiocytoma in the bone can include:
- Pain in the affected area, which may worsen over time or with activity.
- Swelling or a noticeable lump on or around the bone.
- Increased susceptibility to fractures in the affected bone.
- Reduced mobility if the tumour is near a joint.
- General symptoms like fatigue, weight loss, or fever may occur in more advanced stages.
Disease Aetiology (Causes)
The exact cause of MFH of the bone is not well understood. Factors that might contribute include genetic mutations and a prior history of radiation therapy or chronic bone inflammation. However, these factors are not definitive or consistent for all cases.
Diagnosing MFH of the bone typically involves:
- Physical Examination: To identify any visible or palpable lumps and assess pain or swelling.
- Imaging Studies: MRI, CT scans, and X-rays to determine the size, location, and impact of the tumour on surrounding tissues.
- Biopsy: A tissue sample from the affected bone is essential for a definitive diagnosis. Histological examination can distinguish MFH from other types of bone sarcomas.
- Bone Scans and PET Scans: To check for metastasis and the extent of the disease.
Treatment for MFH of the bone usually involves a combination of approaches:
- Surgery: The primary treatment method aims to remove the tumour completely along with a margin of healthy tissue.
- Radiation Therapy: Often used post-surgery to target any remaining cancer cells, or in cases where surgery isn’t possible.
- Chemotherapy: Typically used for high-grade tumours, especially if there’s a risk of cancer spreading.
- Targeted Therapy: In cases where specific genetic markers are present, targeted therapies can be effective.
What support can we give for Malignant Fibrous Histiocytoma of the Bone?
Malignant Fibrous Histiocytoma of the Bone is a rare cancer, meaning it is not as well-known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Malignant Fibrous Histiocytoma of the Bone, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
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