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Granulomatous Slack Skin (GSS)

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Posted by | Mar 17, 2025

What is Granulomatous Slack Skin (GSS)?

Granulomatous Slack Skin (GSS) is a very rare type of skin lymphoma (a type of blood cancer that affects the skin). It causes the skin to become loose, wrinkled, and saggy, usually in areas like the armpits and groin. It develops slowly and isn’t usually aggressive, but in some cases, it can turn into a more serious form of lymphoma.

What Causes It?

Doctors aren’t exactly sure what causes GSS, but they believe it may be linked to genetic changes and issues with the immune system. It is considered a rare type of mycosis fungoides, a slow-growing skin lymphoma.

Symptoms to Look Out For

  • Loose, saggy skin, especially in the armpits and groin
  • Mild itching or discomfort in affected areas
  • Skin becoming thicker over time
  • Swollen lymph nodes in some cases

How is GSS Diagnosed?

Doctors use several tests to confirm GSS, including:

  • Skin biopsy – A small piece of skin is examined under a microscope to check for lymphoma cells.
  • Immunohistochemistry (IHC) – A lab test that looks for specific markers of this type of lymphoma.
  • Blood tests – To check for abnormal immune cells.
  • CT or PET scans – Imaging tests to see if the disease has spread to the lymph nodes.

Treatment Options

While there is no cure, treatment focuses on managing symptoms:

  • Topical steroids & phototherapy – Help relieve skin irritation and slow down the disease.
  • Radiation therapy – Used to treat small, localised skin patches.
  • Systemic treatments (for advanced cases) – Chemotherapy or immunotherapy may be needed if the disease progresses.

What’s the Outlook?

GSS grows slowly, and most people live for many years with proper management. However, in rare cases, it can become more aggressive, so regular check-ups are important.

If you or someone you know is experiencing unusual skin changes, it’s best to see a doctor early for proper diagnosis and care.

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