What is Undifferentiated Carcinoma of Urethra?Undifferentiated carcinoma of Urethra is cancer that originates from the cells of the urethra that line the wall of the urethra, but it is composed of immature and primitive cells and difficult to distinguish from other types of urethral cancer on microscopic examination. It is high-grade cancer. A high-grade tumour is a tumour that grows and spreads quickly. The urethra is a thin tube that starts from the lower opening of the bladder and extends outside the body. Urine is excreted from the body through the urethra. It is the least common among all types of urethral cancers.
Signs and SymptomsIn most cases, symptoms only appear when the disease progresses. The patient may suffer from the following signs and symptoms.
- Urinary retention (it is impossible to empty the bladder completely
- The repeated urge to go to the toilet for urination
- The increased urinary frequency at night
- Passage of blood or blood particles in urine
- Blood spotting from the vagina or urethra
- Flank/loin pain
- Pain at the perineum (pelvis)
- Pain during sexual activity
- Swelling around the perineum
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are
- Urine complete examination (UCE) to detect any urinary tract infection and blood in the urine
- Complete blood count (CBC)
- Renal Function Test (RFT’s) to check the serum urea and creatinine
- Liver function tests (LFT’s)
- Imaging techniques like CT-abdomen and pelvis, USG abdomen and pelvis, MRI, CT-chest, and X-ray to assess the site, size, extent, and distant metastasis of the tumour.
- Cystoscopy; is similar to an ultrasound examination of the ureter, which allows direct visualization of the ureter with cystoscopy.
- Urinary cytology; is a microscopic examination of the cells present in urine and their characteristics.
- Transurethral biopsy