What is Transitional cell Carcinoma with Adenocarcinomatous Differentiation?
It is a rare subtype of transitional cell carcinoma of the bladder that arises from transitional cells of the bladder and consists of glandular mucous secreting cells and transitional cells of the bladder. The colon is most commonly affected, but the urinary bladder can be affected. The tumour tends to metastasis (the tendency of the tumour to spread from its site of origin to the other parts of the body). The tumour can spread to the lower part of the large intestine, stomach, breast, lungs, prostate, and lower genital tract (pelvis) in females.
What is the Urinary bladder and What are its Functions?
The bladder is a sac-like structure in the human body, made up of muscles located in the pelvic region, and its function is to store urine. Urine produced by the kidneys enters the bladder through two tubular structures that originate in each kidney and end in the bladder. The bladder stores urine and helps control urination.
It approximately accounts for 0.5% to 0.2% of all urinary bladder cancers. It is slightly more common in males as compared to females. It usually affects people in their 6th decade of life.
Disease Etiology (Causes)
There is no well-known cause, however, certain genetic mutations (faulty alterations in certain genes) are considered responsible for the development of the disease.
Signs and Symptoms
The patient may suffer from the following signs and symptoms. These are
- (Hematuria) Presence of blood in the urine
- Pain while urination
- Pain in the abdomen
- Usually diagnosed in advanced stages
- Pain while passing urine
- Constant fever
- Unexplained loss of weight
- Constant feeling of tiredness
- Excessive sweating at night
The following diagnostic tests and procedures can be used to make a diagnosis. These are
- Urine complete examination (UCE) to detect any urinary tract infection and blood in the urine
- Complete blood count (CBC)
- Renal Function Test (RFT’s) to check the serum urea and creatinine
- Liver function tests (LFT’s)
- Imaging techniques like CT-abdomen and pelvis, USG abdomen and pelvis, MRI, CT-chest, and X-ray to assess the site, size, extent, and distant metastasis of the tumour.
- Cystoscopy; is similar to an ultrasound examination of the urinary bladder, which allows direct visualization of the ureter with cystoscopy.
- Urinary cytology; is a microscopic examination of the cells present in urine and their characteristics.
- Tumour biopsy and histopathological examination
Surgical resection (cutting off the tumour or diseased part and rejoining the reaming healthy part of the organ or tissue to keep it functional) of the tumour along with radiation therapy and chemotherapy is the main treatment option.
What Support can we Give for Transitional cell Carcinoma with Adenocarcinomatus Differentiation?
Transitional cell Carcinoma with Adenocarcinomatus Differentiation is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Transitional cell Carcinoma with Adenocarcinomatus Differentiation, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
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