What is Transitional cell Carcinoma of the Urinary bladder with Squamous Differentiation?
Transitional cell carcinoma of the bladder with squamous cell differentiation is a type of cancer that consists of a mixed component of epithelial and squamous cells of the urinary bladder. Its site of origin is the walls of the urinary bladder. Among all transitional cell carcinomas of the bladder, 21% are transitional cell carcinomas with squamous cell differentiation. It shows a poor prognosis (the likely course of the disease with treatment).
Disease Etiology (Causes)
There is no well-known cause, however, certain genetic mutations (faulty alterations in certain genes) are considered responsible for the development of the disease.
Signs and Symptoms
There are no certain symptoms but the patient may suffer from the following signs and symptoms. These are
- (Hematuria) Presence of blood in the urine
- Pain in the abdomen
- Pain while passing urine
- Constant fever
- Unexplained loss of weight
- Constant feeling of tiredness
- Excessive sweating at night
Diagnosis
The following diagnostic tests and procedures can be used to make a diagnosis. These are
- Urine complete examination (UCE) to detect any urinary tract infection and blood in the urine
- Complete blood count (CBC)
- Renal Function Test (RFT’s) to check the serum urea and creatinine
- Liver function tests (LFT’s)
- Imaging techniques like CT-abdomen and pelvis, USG abdomen and pelvis, MRI, CT-chest, and X-ray to assess the site, size, extent, and distant metastasis of the tumour.
- Cystoscopy; is similar to an ultrasound examination of the urinary bladder, which allows direct visualization of the ureter with cystoscopy.
- Urinary cytology; is a microscopic examination of the cells present in urine and their characteristics.
- Tumour biopsy and histopathological examination
Treatment
Surgical resection (cutting off the tumour or diseased part and rejoining the reaming healthy part of the organ or tissue to keep it functional) of the tumour along with chemotherapy is the main treatment option. It does not respond well to radiation therapy.
What Support can we Give for Transitional cell Carcinoma of the Urinary bladder with Squamous Differentiation?
Transitional cell Carcinoma of the Urinary bladder with Squamous Differentiation is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Transitional cell Carcinoma of the Urinary bladder with Squamous Differentiation, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
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