What is Sézary Syndrome?
Sézary syndrome is an aggressive type of skin cancer that results from the rapid, uncontrolled division of T lymphocytes. T lymphocytes or T cells are white blood cells. They are a major component of the body’s immune system. They play a role by directly killing infected host cells, activating other immune cells, and regulating the body’s immune system.Disease Etiology (Causes)
There is no well-known cause. However, certain chromosomal abnormalities or genetic mutations (faulty alterations in the genes) are considered responsible for the development of Sézary syndrome.Disease Epidemiology
It is a rare disease and makes approximately 3-5% of all cutaneous T-cell lymphoma.Signs and Symptoms
The patient may suffer from the following signs and symptoms. These are- Itching rash that covers a large portion of the body skin
- Swollen or enlarged lymph nodes
- Hair loss (alopecia)
- Swelling or edema of the skin
- The thick skin of the palms and soles
- Outward turning of the lower eyelid
- It can also affect the spleen, liver, and bone marrow
Diagnosis
The following are the diagnostic tests and procedures that can be used to make a diagnosis. These are- Complete blood count (CBC) with peripheral smear
- Blood coagulation profile
- Tumour biopsy
- Immunohistochemistry
- CT- scan, MRI, PET scan, Ultrasonography (USG), and X-Ray to detect the site and extent of cancer.
Treatment
The most commonly practised and effective treatment therapy in the case of sézary syndrome is chemotherapy alone or chemotherapy with radiotherapy.What Support can we Give for Sézary Syndrome?
Sézary Syndrome is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Sézary Syndrome, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
