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Primary Effusion Lymphoma – Symptoms, Treatment & Support

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Posted by adeel | Jun 6, 2021

What is Primary Effusion Lymphoma?

Primary effusion lymphoma is a rare malignant (cancerous) diffuse large B-cell lymphoma associated with human herpesvirus-8 (HHV-8). Primary effusion lymphoma develops in the pleural (lung), pericardial (heart), and abdominal (abdominal) cavities of the body. Primary effusion lymphoma causes effusion (fluid accumulation) in these body cavities, which can lead to suffering and death. In rare cases, primary effusion lymphoma develops in the joints and the protective layers of the brain and spinal cord.

What are B and T Cells?

There are two types of lymphocytes, B lymphocytes (B-cells) and T lymphocytes (T –cells). These are white blood cells that protect the body against various disease-causing agents such as viruses and bacteria

Disease Epidemiology

It makes approximately 1% of non-AIDS-related white blood cancers and 3% of AIDS-related lymphomas. It is more common in males as compared to females. It usually affects people with weakened immune systems and the elderly.

Disease Etiology (Causes)

There is no known cause, but an association has been found between infection with human herpesvirus-8 (HVV-8) or human immunodeficiency virus (HIV) and the development of primary effusion lymphoma.

Signs and Symptoms

The patient may suffer from the following signs and symptoms. These are
  • Difficulty in breathing
  • Cough
  • Chest pain
  • Distension of the abdomen
  • Diarrhea
  • Fever
  • Weight loss

Diagnosis

Serological, radiological, and biopsy investigations are useful to diagnose. These are:
  • Complete blood count (CBC) with peripheral smear and blood culture
  • Blood coagulation profile
  • LFT’s(Liver function tests) and RFT’s( Renal function tests)
  • Bone marrow aspiration and biopsy
  • Chest X-ray, CT chest
  •  Echocardiography
  • Lumbar Puncture
  • Immunohistochemistry

Treatment

Primary effusion lymphoma usually does not respond to chemotherapy. Highly active antiretroviral therapy in combination with chemotherapy is a treatment for primary effusive lymphoma.
   

What Support can we Give for Primary Effusion Lymphoma?

Primary Effusion Lymphoma is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Primary Effusion Lymphoma we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!

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You can help us with your donation:

Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.

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