What is Precursor B-Lymphoblastic Leukemia?
It is an aggressive type of white blood cell cancer (leukemia) in which too many immature B-cells are found in the bone marrow and blood. It is the most prevalent acute lymphoblastic leukemia. It is also known as precursor B-lymphocytic leukemia. The most commonly affected organs are bone marrow, blood, lymph nodes, spleen, liver, and testes.
Disease Causes
There is no well-known cause; however, certain genetic mutations and risk factors, such as exposure to certain radiation, previous radiation therapy, and previous chemotherapy for cancer treatment, are thought to be responsible for the development of a precursor of B-lymphoblastic leukemia.
Signs and Symptoms
The patient may suffer from the following signs and symptoms. These are
- Anemia ( paleness of the palms and eyes, Difficulty In breathing while doing any physical activity, Constant Fatigue, memory weakness).
- Symptoms of thrombocytopenia (decreased platelet count): easily bleeding and bruising on minor injury, small red or purple spots under the skin, bleeding from nose or gums, unusually heavy menstrual bleeding, recurrent headache.
- Symptoms of neutropenia (abnormally low white blood cell count): Lymphocytes (white blood cells) help to fight infection and microorganisms that enter the body. An abnormally low white blood cell count can produce symptoms of constant fever, chills or sweating, sore throat, diarrhea, cough, and shortness of breath.
- Enlargement of the lymph nodes
- Enlargement of the spleen
- Pain in the bones
- Pain in the joints
Diagnosis
The following diagnostic tests and procedures can be used to make a diagnosis. These are
- Urine complete examination (UCE) to detect any urinary tract infection and blood in the urine
- Complete blood count (CBC)
- Liver function tests (LFT’s)
- Imaging techniques like CT scan, USG, MRI, CT-chest, and X-ray to assess the site, size, extent, and distant metastasis of the tumor.
- Tumor biopsy and histopathological examination
- Bone marrow biopsy
- Immunohistochemistry
Treatment
Chemotherapy, radiation therapy, immunotherapy, targeted therapy, and the stem cell transplantation are the main treatment option.
What support can we give for Precursor B-Lymphoblastic Leukemia?
Precursor B-Lymphoblastic Leukemia is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. We provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from a rare cancer such as Precursor B-Lymphoblastic Leukemia, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways: Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences. Sponsorship — If you wish to sponsor our charity, please contact us using this form. Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
