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Neuroblastoma (Mediastinum) – Symptoms, Treatment & Support

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Posted by adeel | Oct 18, 2020

What is Mediastinal Neuroblastoma?

Mediastinal neuroblastoma is a solid tumour that arises from neuroblasts, these tumour cells migrate during embryonic development along the axis of the central nervous system (i.e. the brain and spinal cord) and colonize in the mediastinum. It usually develops in children under 1 year of age. 

What are Neuroblasts?

Neuroblasts are primitive nerve cells that make up neurons. Neurons are a fundamental structural and functional unit of the nervous system that specializes in transmitting information throughout the body.

What is Mediastinum?

The mediastinum is the part of the chest or chest cavity that consists of the heart, thymus, part of the esophagus, and the trachea.

Disease Etiology (Causes) of Neuroblastoma (Mediastinum)

There is no well-known cause of mediastinal neuroblastoma. However certain genetic mutations (alterations) are thought to be responsible.

Disease Epidemiology

The incidence of mediastinal neuroblastoma is approximately 9.5 cases per million children worldwide. The five-year survival rate is approximately 55%. It is slightly more common in male children than in the female. Usually, this disease is diagnosed more often in children under 2 years of age.

Signs and Symptoms

The patient may suffer from the following signs and symptoms. These are

  • Chronic dry cough
  • Chest pain
  • Difficulty in breathing
  • Nausea or vomiting
  • Weight loss
  • Fatigue
  • Body pains
  • Fever
  • Night sweats

Diagnosis

The following diagnostic tests and procedures can be used to make a diagnosis. These are

  • (Computerized tomography) CT-chest and PET scan are standard imaging techniques to rule out mediastinal neuroblastoma.
  • ECG
  • Echocardiogram
  • Elevated HMA and VMA
  • Tumour biopsy and histopathological examination

In a clinical case of posterior mediastinal neuroblastoma, clinical characteristics and radiographic images were identified.

Treatment

The main treatment options are surgical removal of the tumour and chemotherapy.


What Support can we Give for Neuroblastoma (Mediastinum)?

Neuroblastoma (Mediastinum) is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Neuroblastoma (Mediastinum), we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!

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You can help us with your donation:

Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:

Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.

 

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