What is Methotrexate-Associated Lymphoproliferative Disorder?
The methotrexate-associated lymphoproliferative disease is a non-malignant rapid division or proliferation of lymphocytes (white blood cells) producing tissues or organs in patients taking methotrexate. Methotrexate is a medicine used to treat certain types of leukocyte cancers, cancers of the skin, lungs, head, neck, and uterus. Methotrexate is also used to relieve the symptoms of joints pain and swelling in Rheumatoid arthritis. The most commonly affected sites are lymph nodes, tonsils, thymus, spleen, and bone marrow. Less frequently involved sites are the stomach and the large intestine.
Disease Etiology (Causes)
An association with methotrexate intake, history of rheumatoid arthritis, and Epstein-Barr virus infection has been observed in the development of methotrexate-associated lymphoproliferative disorder.
Signs and Symptoms
Signs and symptoms differ depending on the location of the lesion or organ involvement. For example, a patient with abdominal (stomach or large intestine) lymphoproliferative disease associated with methotrexate may suffer from the following signs and symptoms.
- Pain in the abdomen
- Difficulty in breathing
- Distension of the abdomen
- Nausea
- Vomiting
- Fever
- Constant feeling of tiredness
- Night sweats
Diagnosis and Treatment
Common diagnostic tests and procedures for diagnosing the methotrexate-associated lymphoproliferative disorder are;
- Imaging techniques like USG, CT-scan, PET-scan, MRI, and X-ray.
- Bone marrow and affected tissue biopsy.
- Immunohistochemistry
- Endoscopy in a case where the lymphoma is of gastrointestinal origin.
- Bronchoscopy where the lymphoma is originated from lung tissues.
- Ureas breathe test or stool antigen test for H.Pylori.
Treatment
Discontinuation of the methotrexate or discontinuation of the methotrexate along with chemotherapy is the recommended treatment option.
What Support can we Give for Methotrexate-Associated Lymphoproliferative Disorder?
Methotrexate-associated Lymphoproliferative Disorder is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Methotrexate-Associated Lymphoproliferative Disorder we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
