What is Large Cell Neuroendocrine Carcinoma of the Lung?Large cell neuroendocrine carcinoma of the lung is a rare type of lung cancer that accounts for 1-3% of all lung cancers. It shows poor prognosis (likely course of the disease). The five year survival rate of large cell neuroendocrine carcinoma of the lung is 35%. It has the tendency to recur after surgical removal of the tumor. It usually invades adjacent organs of the lungs, such as the outer layer of the lining of the lungs, called the pleura, and the wall of the chest cavity. It is more common in males as compared to females. It usually develops in older people who have a history of heavy cigarette smoking.
Disease CausesThere is no well-known cause. However, there is a strong link between the presence or diagnosis of large cell neuroendocrine carcinoma of lung and chronic tobacco smoking. Other risk factors for developing large cell lung cancer are the working history in uranium mines and long-term exposure to radon gas.
Signs and SymptomsSigns and symptoms depend on the extent and spread of the disease to other organs or parts of the body. If the cancer is limited to the lungs, the patient will only experience signs and symptoms of the respiratory system. At the same time, in cases where this cancer spreads to other parts of the body, the patient also experiences B symptoms of cancer.
General respiratory symptoms of large cell neuroendocrine carcinoma of lung
- Persistent cough
- Dyspnea (shortness of breath or difficulty in breathing)
- Chest pain that worsens with coughing, laughing and breathing deeply
- Coughing up blood
- Wheezing without having asthma history
- Clubbing of the fingers and nails (A physical sign characterized by a bulging extension at the ends of one or more fingers or toes).
- Excessive sweating at night
- Weight loss
- Bone pains
- Imaging techniques like Chest X-ray, CT-scan, MRI, and PET scan to see the site, size, and extent of the tumor.
- Tumor biopsy ( lung tumor biopsy to remove a small sample of lung tissue for histopathological examination)
- Sputum cytology
- USG guided fine needle aspiration cytology