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Hepatosplenic T cell Lymphoma – Symptoms, Treatment & Support

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Posted by adeel | Dec 20, 2020

What is Hepatosplenic T cell Lymphoma?

Hepatosplenic T cell lymphoma is a rare cancer that results from the excessive and uncontrolled production of white blood cells, especially cytotoxic T cells that invade the spleen, liver, and bone marrow. Neutrophils, basophils, eosinophils, T cells, and B cells are types of white blood cells. Lymphocytes (white blood cells) help to fight infection and microorganisms that enter the body. Hepatosplenic T cells lymphoma is usually incurable.

Disease Etiology (Causes)

There is no definite well-known cause. But certain genetic mutations and risk factors, such as a history of immunosuppressants (drugs that suppress allergies and medications given after organ transplants), HIV, and inflammatory bowel disease are factors that contribute to the development of hepatosplenic T-cell lymphoma.

Disease Epidemiology

Hepatosplenic T cell lymphoma is rare cancer that accounts for less than 5% of all lymphoma cases. It usually develops in the younger and adolescent population. Hepatosplenic T cell lymphoma is slightly predominant in males as compared to females.

Signs and Symptoms

The patient may suffer from the following signs and symptoms. These are
  • Enlargement of the spleen and liver
  • Pain in the abdomen
  • Enlargement of lymph nodes
  • Fever
  • Night sweats
  • Bone pains
  • Lethargy
  • Weakness

Diagnosis

Serological, radiological, and biopsy investigations are useful to diagnose. These are:
  • Complete blood count (CBC) with peripheral smear and blood culture
  • Blood coagulation profile
  • LFT’s(Liver function tests) and RFT’s( Renal function tests)
  • Bone marrow aspiration and biopsy
  • MRI (Magnetic Resonance Imaging) and USG (Ultrasonography) of abdomen

Treatment

Treatment options include surgery, chemotherapy radiotherapy, and autologous stem cell transplantation. Treatment recommendations vary according to the staging of the lymphoma /malignancy and general health condition of the patient.

What Support can we Give for Hepatosplenic T cell Lymphoma?

Hepatosplenic T cell Lymphoma is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Hepatosplenic T cell Lymphoma we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!

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You can help us with your donation:

Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:
Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.

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