What are Glandular MPNs?
Glandular Myeloproliferative Neoplasms (MPNs) are blood cancers that develop when the body (bone marrow) produces excessive numbers of mature white blood cells, red blood cells, and platelets. White blood cells help the body to fight against infections; red blood cells help the body in supplying oxygen and nutrients to the body cells while platelets are blood clotting cells and are responsible for making clots in case of injury to prevent the excessive blood flow from the injured part of the body. According to the World Health organization, 2008 Glandular MPNs classification following blood disorders comes under the classification.
- Classic MPNS polycythemia vera
- Essential Thrombocytopenia
- Primary idiopathic Myelofibrosis
Disease Etiology (Causes)
The cause behind the development of nodular MPNs is poorly understood, however, mutations in the JKA2, MPL, or CALR genes are held responsible for its development.
Signs and Symptoms
- Initially, there is increased production and the presence of blood cells count in the bone marrow. And in peripheral blood, there is also increased production and maturation of blood cells in the spleen and thymus. This leads towards enlargement of spleen and fibrosis (scars) in the bone marrow.
- Laterally there is a reduction in the number of red blood cells, white blood cells and platelets which can produce symptoms of anemia (like shortness of breath, fatigue, and lethargy), thrombocytopenia or decreased platelet counts (easy bruising and bleeding) and leukopenia or decreased white blood cells count (repeated infections due to decreased WBCs).
- Enlarged and Swollen lymph nodes
- Pulmonary arterial hypertension( high blood pressure in the arteries of the lungs)
- People who have Glandular MPNs have prolonged survival as compared to other cancers.
Diagnosis and Treatment
We can use the following diagnostic tests to make a diagnosis.
- Complete blood count (CBC) with peripheral smear
- Blood coagulation profile
- Bone marrow aspiration and cytology
- Immunophenotyping Analysis through flow cytometry or immunohistochemistry.
Treatment options include chemotherapy and autologous haematopoietic stem cell transplantation.
What support can we give for Glandular MPNs?
Glandular MPNs is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. We provide a designated platform for Warriors to obtain information specific to their Rare Cancer. In addition, we also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer, such as Glandular MPNs, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!
You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways: Donations — Without a Ribbon is grateful when donations are received. Giving to Without a Ribbon helps us to provide ongoing support, organize the annual gathering and subsidise the costs of our Warriors attending these conferences. Sponsorship — If you wish to sponsor our charity, please contact us using this form. Volunteering — We are always looking for volunteers to help with different aspects of running our charity. If you are looking for volunteer work, please feel free to contact us.