What is a Gastrointestinal Stromal?
A gastrointestinal stromal tumor is a tumor that originates from the cells which are present in the wall of the gastrointestinal tract called interstitial cells of Cajal(ICCs). These cells are also named as the pacemakers of the gastrointestinal tract because they convey signals to the muscles of the gastrointestinal tract which helps the GIT in the mobility of the food through contraction and relaxation of GIT musculature. Gastrointestinal tumors can arise from any part of the GIT (gastrointestinal tract) but most commonly they arise from the stomach and small intestine.What is a Gastrointestinal Stromal Tumor Of The Colon?
Gastrointestinal stromal tumor of the colon is cancer that originates from the interstitial Cajal cells of the large intestine named colon. These tumors account for only 0.1% of all gastrointestinal stromal tumors.Disease Etiology (Causes)
They may develop due to mutations in a certain gene name c-kit proto-oncogene. It is also associated with some hereditary syndromes (a combination of diseases) like irritable bowel syndrome, cutaneous hyperpigmentation, dysphagia, Carney triad, neurofibromatosis type 1 and diverticular disease.Disease Epidemiology
Among all types of gastrointestinal tumors, gastrointestinal stromal tumors are 1-3%. The overall 5-year survival rate for patients with GISTs is 77% among those diagnosed with localized diseases, 64% among those with regional diseases, and 41% with metastatic diseases according to disease surveillance epidemiology result of 2001-2011. It is more common in males as compared to females. The risk of development of the tumor increase with age reaches a maximum after the 7th decade of life. Small size gastric gastrointestinal stromal tumors (GISTs) have a better prognosis (the likely course of the disease) as compared to small size intestinal GITs.Signs and Symptoms
Gastrointestinal stromal tumor of the colon is usually asymptomatic but may present with the following signs and symptoms. These are- Melena ( black color stool due to bleeding from the upper gastrointestinal tract)
- Malaise, fatigue, and difficulty in breathing while walking or doing any physical activity due to loss of blood from the ulcerated site of the tumor.
- Abdominal pain
- Nausea
- Vomiting
- Loss of appetite
- Loss of body weight
- Feeling of fullness even after a few mouthfuls
Diagnosis and Treatment
A diagnosis can be made through by- Complete blood count (CBC)
- Blood coagulation profile
- BUN ( blood urea and nitrogen)
- Serum creatinine
- Liver function tests LFT’s
- Amylase and lipase values
- Imaging techniques like CT-scan, MRI, PET-scan, X-Ray, and USG to detect the site and size of the tumor.
- Endoscopy
- Preoperative biopsy
Treatment
Surgical resection (removal or cutting of the diseased part through surgery) is the most common and effective treatment option.What Support can we Give for Gastrointestinal stromal tumors of the colon?
Gastrointestinal stromal tumors of the colon is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Gastrointestinal stromal tumors of the colon we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!You can help us with your donation:
Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:Donations — Without a Ribbon is grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
Sponsorship — If you wish to sponsor our charity, please contact us using this form.
Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.
