What is Follicular Dendritic Cell Sarcoma?Follicular dendritic cell sarcoma is an uncommon type of blood cancer that usually develops from the dendritic cells of the lymph nodes. Dendritic cells are antigen-presenting cells, those cells of the immune system that represent foreign bodies or harmful pathogens to the disease-killing cells of the immune system.
What are Lymph Nodes?Lymph nodes are small glands in the human body that filter lymph. Lymph is a clear fluid that circulates in the body through the lymphatic system. The lymph nodes of the lymphatic system help to fight against various infections.
Disease EtiologyThere is no well-known cause. However, clinical and biological studies show that there is a strong link between castle man’s disease and the development of follicular dendritic cell sarcoma. Castle man’s disease is a condition in which benign (non-malignant) growths or tumors develop in the lymph nodes. There is also a link between Epstein-Barr virus infection and the development of sarcoma of follicular dendritic cells of the liver and spleen.
Disease EpidemiologyIt is rare cancer. The average age at development of follicular dendritic cell sarcoma is 5th decade, but cases of follicular dendritic cell sarcoma have also been reported in children.
Signs and symptomsThe patient may suffer from the following signs and symptoms. These are
- Slowly growing painless mass or growth
- High-grade fever
- Weight loss
- Night sweats
DiagnosisThe following diagnostic techniques and procedures can be used to make a diagnosis. These are
- Imaging studies such as X-ray, CT-scan, and MRI to detect the site, size, and extent of the metastasis (spread of the tumor)
- CT chest, the scan of bones, and PET-Scan to assess the areas and spread of the tumor
- Lymph node biopsy / Tumor biopsy