What is Duodenal Adenocarcinoma of the Small Intestine?Duodenal adenocarcinoma of the small intestine is a rare type of high-grade cancer that accounts for less than 1% of all cancers of the gastrointestinal tract ( gastrointestinal tract is a tract system through which food passes and digest, it consists of mouth, throat, esophagus, stomach, small intestine, large intestine, and rectum). Adenocarcinoma of the duodenum originates from the uncontrolled growth of the cells that secretes the enzymes and digestive secretions that are used in the digestion of cells.
What is Duodenum?Duodenum is the first part of the small intestine that connects to the stomach. Duodenum further digests the food coming from the stomach and absorbs nutrients and water from the food back into the bloodstream.
Disease CausesThere is no well-known cause, however, certain hereditary and genetic mutations are considered responsible for the development of duodenal adenocarcinoma of the small intestine. The risk factors for the development of duodenal adenocarcinoma of the small intestine include a low-fibre diet, increase consumption of processed foods such as bread, pasta, red meat, and sugar, as well as physical inactivity.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- Pain in the abdomen
- Loss of appetite
- Blood in vomiting
- Dark color stool due to the presence of blood in stool
- Obstruction of the intestine which appears as a sign and symptom of protruding abdomen, bloating of the abdomen, cramps in the abdomen, severe constipation, and loss of appetite
- In advanced stages of the disease, patient may suffer from unexplained weight loss, constant fever, and fatigue
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis. These are
- Ultrasound (USG) of the abdomen
- Endoscopic examination of the anus, rectum, small intestine, and large intestine. Endoscopy is a procedure that allows the doctor to visualize the internal organs of the body directly through the endoscope.
- Computed tomography (CT-pelvis) helps to differentiate the types of cells involved in cancer
- Biopsy of the lesion/tumour and histopathological examination
- Barium Meal