What is Cutaneous Angiosarcoma or Angiosarcoma of the Skin?Angiosarcoma of the skin is a rare type of skin cancer that originates from the uncontrolled division or multiplication of cells that make the lining of blood vessels or lymph vessels. Lymph vessels are part of the lymphatic and immune systems of the body, these vessels run throughout the body and carry lymph (a clear fluid). The lymphatic system consists of lymph, lymphatic vessels, lymph nodes, collecting ducts, and the spleen. The main function of the lymphatic system is to protect the body from illness by collecting and destroying bacteria, viruses, and waste products of the body. It usually appears as a bruise-like purplish lesion on the skin that grows gradually over time. These areas get start bleeding on doing itching on the area of lesion or bruise.
Disease CausesThere is no well-known cause, however, certain hereditary and genetic mutations (faulty changes in DNA) are considered responsible for the development of angiosarcoma of the skin. Some potential risk factors are the history of chemotherapy, swelling caused by damage of lymph vessels, exposure to certain chemicals such as vinyl chloride and arsenic, and certain genetic syndromes such as neurofibromatosis, Maffucci syndrome, and the presence of BRCA1 and BRCA2 genes.
Signs and SymptomsThe patient may suffer from the following signs and symptoms. These are
- Lesion or raised mass on the skin
- The purplish bruise that grows larger over time
- Bleeding from the lesion on doing itch or scratch
- Swelling around the skin lesion
- Narrow margin excisional biopsy