What is comedo-type ductal carcinoma in situ?A Comedogenic ductal carcinoma in situ is high-grade cancer in which high-grade cancer cells fill and dilate the ducts and lobules of the breast. The tumor tends to recur and invade the underlying tissues. However, it shows a good prognosis (the likely course of the disease) with treatment.
Disease etiology (causes)There is no well-known cause, however, certain mutations in the breast cancer gene 1 (BRCA1) and (BRCA2) are thought to be responsible for the development of comedogenic ductal carcinoma in situ.
Signs and symptomsThe patient may suffer from the following signs and symptoms. These are
- A palpable lump or mass in the breast
- Redness of the breast
- Breast rash
- Thickening of the breast skin
- Abnormal nipple discharge
- Dimpling in the nipple or around the nipple
- Pain in the breast
DiagnosisThe following diagnostic tests and procedures can be used to make a diagnosis.
- Mammography ( X-Ray breast)
- CT-scan, MRI, and PET scan to see the size, site, and extent of the tumor.
- Skin biopsy
- FNA( Fine needle aspiration) or core needle biopsy; are diagnostic procedures in which a sample of cells from a mass or lump is taken using a fine needle, which is then examined under a microscope.
- Histopathological examination