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Clear Cell Carcinoma of the Uterus

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Posted by Matthew O’Connor | May 30, 2023

What is Clear Cell Carcinoma of the Uterus?

Clear cell carcinoma of the uterus is a rare and aggressive type of endometrial cancer characterised by the presence of clear cells and hobnail cells. It represents only a small fraction of all endometrial cancers. However, it tends to be more aggressive and has a poorer prognosis than more common types of endometrial cancer.

Symptoms

Symptoms of clear cell carcinoma of the uterus may include:

  • Abnormal vaginal bleeding or discharge
  • Pain during intercourse
  • Pelvic pain
  • A palpable mass or lump in the pelvic area
  • Unexplained weight loss

Disease Aetiology (Causes)

The exact cause of clear cell carcinoma of the uterus is unknown, but it may be associated with a history of pelvic radiation therapy and certain genetic mutations. Other potential risk factors for endometrial cancer, in general, include obesity, estrogen therapy without progesterone, late menopause, and never having been pregnant.

Diagnosis

The diagnosis of clear cell carcinoma often involves:

  • Detailed medical history and physical examination
  • Endometrial biopsy or dilation and curettage (D&C) to obtain tissue for examination under a microscope
  • Imaging tests such as ultrasound, CT scan, or MRI to ascertain the size, location, and extent of the tumour

Treatment

The treatment for clear cell carcinoma of the uterus typically involves:

  • Surgery: The primary treatment, involves the surgical removal of the uterus (hysterectomy), along with the fallopian tubes and ovaries.
  • Radiation Therapy: This can be used after surgery to kill any remaining cancer cells and reduce the risk of recurrence.
  • Chemotherapy: This is often used in combination with surgery, particularly in more advanced cases or if the cancer recurs.

What Support can we Give for Clear Cell Carcinoma of the Uterus?

Clear Cell Carcinoma of the Uterus is rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Clear Cell Carcinoma of the Uterus, we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today!

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Without a Ribbon is a charity that works hard to aid those who suffer from rare cancers. You can help our cause in a variety of ways:

Donations — Without a Ribbon are grateful when we receive every donation. Giving to Without a Ribbon helps us to provide ongoing support, organise the annual gathering and subsidise the costs of our Warriors attending these conferences.
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Volunteering — We are always looking for volunteers to help with different aspects of running our charity. So, if you are looking for volunteer work, please feel free to contact us.

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